Association of Reduced Folate Carrier-1 (RFC-1) Polymorphisms with Ischemic Stroke and Silent Brain Infarction
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چکیده
منابع مشابه
Association of Reduced Folate Carrier-1 (RFC-1) Polymorphisms with Ischemic Stroke and Silent Brain Infarction
Stroke is the second leading cause of death in the world and in South Korea. Ischemic stroke and silent brain infarction (SBI) are complex, multifactorial diseases influenced by multiple genetic and environmental factors. Moderately elevated plasma homocysteine levels are a major risk factor for vascular diseases, including stroke and SBI. Folate and vitamin B12 are important regulators of homo...
متن کاملEffect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (RFC-1)
Arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. The hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (NTDs) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. In this study, sodium arsenate was administered via intraperitoneal route at a r...
متن کاملAssociation between VEGF polymorphisms and homocysteine levels in patients with ischemic stroke and silent brain infarction.
BACKGROUND AND PURPOSE Vascular endothelial growth factor (VEGF) plays a role in atherosclerosis-related diseases such as cerebrovascular or cardiovascular diseases. However, the effect of VEGF -2578C>A, -1154G>A, -634G>C, and 936C>T polymorphisms on the susceptibility to stroke and silent brain infarction has not been reported. METHODS Using polymerase chain reaction-amplified DNA, VEGF poly...
متن کاملeffect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (rfc-1)
arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. the hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (ntds) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. in this study, sodium arsenate was administered via intraperitoneal route at a r...
متن کاملClinical Sciences Association Between VEGF Polymorphisms and Homocysteine Levels in Patients With Ischemic Stroke and Silent Brain Infarction
Background and Purpose—Vascular endothelial growth factor (VEGF) plays a role in atherosclerosis-related diseases such as cerebrovascular or cardiovascular diseases. However, the effect of VEGF-2578CϾA,-1154GϾA,-634GϾC, and 936CϾT polymorphisms on the susceptibility to stroke and silent brain infarction has not been reported. Methods—Using polymerase chain reaction-amplified DNA, VEGF polymorph...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0115295